Nový indocyaninový zelený CAS 172616-80-7

Nový indocyaninová zeleň, také známý jako IR-820, je typ barviva v blízkém infračerveném (NIR) spektru, který má významnou hodnotu pro výzkum v životních vědách a biomedicínských studiích. Vyskytuje se jako hnědá krystalická látka s bodem tání nad 300 stupňů. V akválním roztoku vykazuje široké absorpční pásmo při 690 nm a má molární absorpci 72 x 10^4 dm³·mol⁻¹·cm⁻¹. To z něj činí vynikající volbu pro různé aplikace v medicíně.

Jako nákladově efektivní zobrazovací činidlo s nízkou cytotoxicitou se používá v obrazově řízené fototermální terapii pro léčbu rakoviny. Slouží také jako kontrastní činidlo pro detekci a kvantifikaci infikovaných tkání u zvířat. Dále jeho použití jako fluorescenčního markeru ve výzkumu léčiv podtrhuje jeho význam v biomedicínských vědách.

Ve shrnutí, jedná se o všestranný barvivo v blízké - infračervené oblasti s širokým spektrem využití v lékařském zobrazování, terapii a výzkumu. Jeho jedinečné vlastnosti z něj činí cenný nástroj při pokračujícím rozvoji biomedicínského výzkumu a metod léčby.

(IR-820) is a dye with near-infrared absorption properties. Its unique chemical structure and optical properties make it widely applicable in various fields such as medicine, laser and infrared technology.

 

1. Medical imaging and diagnosis
The application in the field of medical imaging is particularly prominent. As a near-infrared fluorescent dye, it can be excited by specific wavelengths of light and emit near-infrared fluorescence signals, thereby achieving visualization of biological tissues.
Infrared blood pool contrast: It can be used as an infrared blood pool contrast agent, injected into the animal's body through veins or peritoneum, and utilizes its fluorescence characteristics in the near-infrared region to clearly display vascular structure and blood flow dynamics. This characteristic is particularly important in tumor diagnosis, as tumor tissue typically has an abnormal vascular network. Infrared blood pool imaging can accurately identify the lesion area, providing important evidence for subsequent treatment.

 

Detection of pathological tissue in live animals: In live animal experiments, it can specifically aggregate in pathological tissue and achieve precise localization of pathological tissue through fluorescence imaging technology. This non-invasive detection method not only reduces the pain of experimental animals, but also improves the accuracy and reliability of experimental data.
Multimodal imaging: It can also be combined with other fluorescent probes or imaging techniques to achieve multimodal imaging. For example, combining with imaging techniques such as magnetic resonance imaging (MRI) or computed tomography (CT) can provide more comprehensive anatomical and functional information, improving the accuracy and sensitivity of disease diagnosis.

 

2. Tumor treatment
It has also shown great potential in the field of tumor treatment. Its unique near-infrared absorption characteristics make it an ideal photosensitizer for image-guided photothermal therapy and photodynamic therapy.
Image guided photothermal therapy: Under the irradiation of near-infrared light, it can absorb light energy and convert it into heat energy, producing local thermal effects to kill tumor cells. This treatment method has the advantages of precision, minimally invasive, and high efficiency, which can significantly improve the treatment effect of tumors. Meanwhile, real-time monitoring of the treatment process through fluorescence imaging technology can ensure the accuracy and safety of the treatment.

 

Photodynamic therapy: In addition to photothermal effects, it can also generate reactive oxygen species (ROS) under light stimulation, which can damage the DNA and cell membrane structure of tumor cells through oxidative stress response, thereby inducing tumor cell apoptosis. This dual mechanism of action enables neoindocyanine green to have higher efficacy and lower side effects in tumor treatment.
Targeted therapy: By binding neoindocyanine green with specific antibodies or drugs, targeted fluorescent probes or drug carriers can be formed to achieve specific labeling and tracking of tumor cells. This targeted therapy method can significantly improve the efficacy and safety of drugs, and reduce damage to normal tissues.

 

3. Liver function assessment
It also has certain application value in liver function assessment. Although its specific mechanism differs from classical indocyanine green (ICG), a novel liver function assessment method can be developed based on its near-infrared fluorescence properties. For example, by monitoring its metabolism and excretion in the liver, the reserve function and metabolic capacity of the liver can be evaluated, providing important basis for the diagnosis and treatment of liver diseases.

 

1. Near infrared dyes
As an excellent near-infrared dye, it has broad application prospects in the fields of laser and infrared technology. Its high molar absorptivity and wide absorption band make it an ideal gain medium or filter in laser devices.
Laser gain medium: In solid-state lasers, green can be used as a gain medium to achieve high-power and high-efficiency laser emission by absorbing pump light energy and converting it into laser output. This type of laser has wide application value in industrial processing, medical beauty and other fields.
Infrared filter: In infrared optical systems, it can be used as a filter to separate and purify spectra by absorbing specific wavelengths of infrared light and transmitting other wavelengths of light.

 

This type of filter plays an important role in fields such as infrared imaging and infrared communication.

2. Industrial and scientific research applications
In addition to laser equipment, it can also be used in other industrial and scientific research fields. For example, in materials science, its fluorescence properties can be used to study the structure and properties of materials; In environmental science, it can be used as a fluorescent probe to detect pollutants or harmful substances in the environment; In biomedical research, its near-infrared fluorescence properties can be utilized for cell imaging, molecular tracking, and other experiments.

 

1. Biosensors
It has excellent fluorescence properties and chemical stability, making it an ideal candidate material in the field of biosensors. By binding it with specific biomolecules such as antibodies, enzymes, etc., high-sensitivity and high selectivity biosensors can be constructed for detecting target molecules (such as glucose, proteins, DNA, etc.) in biological samples. This type of biosensor has broad application prospects in fields such as disease diagnosis and environmental monitoring.

 

2. Drug development
In the process of drug development, it can be used as a fluorescent marker to monitor the real-time distribution and metabolism of drug molecules in the body. Through fluorescence imaging technology, the accumulation and release kinetics of drug molecules in target tissues can be visually observed, thereby evaluating the efficacy and safety of drugs. In addition, the IR-820 can also be used as a component of drug carriers to enhance drug efficacy and reduce side effects by targeted delivery of drug molecules to diseased tissues.

 

3. Security and anti-counterfeiting measures
can also be used in the fields of security and anti-counterfeiting. For example, it can be added to anti-counterfeiting labels or packaging materials, and emit fluorescent signals under specific excitation light sources to achieve product authenticity identification and traceability tracking. This anti-counterfeiting technology has the advantages of being difficult to replicate and easy to identify, and has wide application value in high-end goods, pharmaceuticals, and other fields.

Contrast agents, also known as contrast media, are chemical substances injected or ingested into the human body's tissues or organs to enhance the effectiveness of imaging observations. These substances, which have a density higher or lower than the surrounding tissues, create a contrast that allows certain imaging devices to produce clearer images.

• : These are the most commonly used contrast agents in interventional radiology. They contain varying concentrations of iodine and are often used in vascular and body cavity imaging. Examples include iopromide (Ultravist), iohexol (Omnipaque), and iopamidol (Isovue). Iodinated contrast agents can be further classified into ionic and non-ionic types. Non-ionic agents are generally less toxic and have a lower incidence of adverse reactions compared to ionic agents.
• : This type of contrast agent is primarily used in gastrointestinal imaging. It is a white, odorless, tasteless powder that is mixed with water to form a suspension. When ingested, it coats the lining of the esophagus, stomach, and small intestine, allowing for better visualization during X-ray examinations.
• Gadolinium-Based Contrast Agents: These agents are used in magnetic resonance imaging (MRI) to enhance the visibility of blood vessels and other structures. They contain gadolinium, a lanthanide element, chelated with various ligands to improve stability and reduce toxicity.

While contrast agents are generally safe, some patients may experience adverse reactions. These can range from mild symptoms such as nausea, vomiting, and edema to severe reactions including anaphylaxis, shock, and coma. Therefore, it is important for healthcare professionals to screen patients for allergies to contrast agents and to monitor them closely during and after the procedure.

• : Iodinated contrast agents can cause kidney damage, particularly in patients with pre-existing renal impairment. Therefore, renal function should be assessed before administering these agents.
• : Since iodinated contrast agents contain iodine, they can affect thyroid function. Patients with hyperthyroidism may be more susceptible to thyroid storms after receiving these agents.

In conclusion, contrast agents are essential tools in medical imaging, enabling healthcare professionals to obtain clearer and more detailed images of the body's internal structures. However, their use should be carefully managed to minimize the risk of adverse reactions.

(IR-820) is a significant near-infrared dye with broad applications in life science and biomedical research. As a cost-effective imaging agent with low cytotoxicity, it has demonstrated remarkable potential in various research instances.

One notable research example involves its use in laparoscopic surgery, particularly in transplant surgery. In a case report, it was employed as a fluorescent imaging agent to identify and locate lymphoceles during a laparoscopic procedure. By injecting ICG into the lymphocele, surgeons could visualize the internal structure of the lymphocele lobes under near-infrared fluorescence imaging. This technique allowed for precise dissection of the lymphocele wall and aspiration of serous fluid, reducing the risk of damaging urinary structures during surgery. The successful application of ICG in this instance underscores its value as a tool for enhancing surgical precision and patient outcomes.

Furthermore, it has been utilized in the detection of sentinel nodes in gastric cancer surgery. Its ability to provide real-time, non-invasive imaging makes it an attractive option for avoiding unnecessary resection and improving surgical accuracy. Additionally, ICG has been explored as a contrasting agent for the detection and quantification of infected tissues in animals, further broadening its scope of applications.

In summary, IR-820 has shown promising results in a variety of research instances, including laparoscopic surgery and cancer imaging. Its unique near-infrared fluorescence properties make it a versatile tool for enhancing visualization and precision in medical research and clinical practice.

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